Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland.
Department of Tourism and Health Promotion, University of Technology, Faculty of Physical Education and Physiotherapy, 45-758 Opole, Poland.
Nutrients. 2017 Jul 26;9(8):803. doi: 10.3390/nu9080803.
Extracts of leaves, a natural source of flavonoids and polyphenolic compounds, are commonly used as therapeutic agents for the improvement of both cognitive and physiological performance. The present study was aimed to test the effects of a six-week supplementation with 160 mg/day of a standardized extract of or a matching placebo on aerobic performance, blood antioxidant capacity, and brain-derived neurotrophic factor (BDNF) level in healthy, physically active young men, randomly allocated to two groups ( = 9 each). At baseline, as well as on the day following the treatment, the participants performed an incremental cycling test for the assessment of maximal oxygen uptake. Venous blood samples taken at rest, then immediately post-test and following 1 h of recovery, were analyzed for activities of antioxidant enzymes and plasma concentrations of non-enzymatic antioxidants, total phenolics, uric acid, lipid peroxidation products, ferric reducing ability of plasma (FRAP), and serum brain-derived neurotrophic factor (BDNF). Our results show that six weeks' supplementation with extract in physically active young men may provide some marginal improvements in their endurance performance expressed as VO₂max and blood antioxidant capacity, as evidenced by specific biomarkers, and elicit somewhat better neuroprotection through increased exercise-induced production of BDNF.
叶子提取物是黄酮类化合物和多酚类化合物的天然来源，常被用作改善认知和生理机能的治疗剂。本研究旨在测试每天补充 160 毫克标准化 提取物或匹配安慰剂对健康、活跃的年轻男性的有氧运动能力、血液抗氧化能力和脑源性神经营养因子 (BDNF) 水平的影响，这些男性被随机分配到两组 (每组 9 人)。在基线时以及治疗后的第二天，参与者进行递增式踏车测试以评估最大摄氧量。在休息时、测试后即刻和恢复 1 小时时采集静脉血样，用于分析抗氧化酶活性和非酶抗氧化剂、总酚类、尿酸、脂质过氧化产物、血浆铁还原能力 (FRAP) 和血清脑源性神经营养因子 (BDNF) 的浓度。我们的结果表明，在活跃的年轻男性中补充 提取物六周可能会通过特定的生物标志物略微提高他们的耐力表现（表现为 VO₂max 和血液抗氧化能力），并通过增加运动诱导的 BDNF 产生来提供更好的神经保护作用。
