Thomas R Z, Loos B G, Teeuw W, Kunnen A, van Winkelhoff A J, Abbas F
Ned Tijdschr Tandheelkd. 2015 Oct;122(10):542-8. doi: 10.5177/ntvt.2015.10.15134.
The evidence for an association between systemic diseases and periodontitis is strongest with diabetes mellitus type 2 and cardiovascular disease. There is a moderate association of periodontitis with adverse pregnancy outcomes and rheumatoid arthritis. Periodontal treatment has, on average, a positive effect on reducing systemic infection and improving the condition of the vascular system. For diabetes patients, periodontal treatment can also have a positive effect on metabolic regulation. There is insufficient evidence that periodontal treatment prevents adverse pregnancy outcomes and rheumatoid arthritis.
全身性疾病与牙周炎之间存在关联的证据，在2型糖尿病和心血管疾病方面最为确凿。牙周炎与不良妊娠结局及类风湿关节炎存在中度关联。牙周治疗总体上对减少全身感染和改善血管系统状况有积极作用。对于糖尿病患者，牙周治疗对代谢调节也可产生积极影响。尚无充分证据表明牙周治疗可预防不良妊娠结局和类风湿关节炎。
