Nayudu Anuradha, Lam Tracie, Ho Jessica, Forghany Ali, Vu Thinh, Ngo William, Ajdaharian Janet, Wilder-Smith Petra
Beckman Laser Institute, University of California, Irvine, CA.
Dentistry (Sunnyvale). 2016 Oct;6(10). doi: 10.4172/2161-1122.1000396. Epub 2016 Oct 18.
Goal of this prospective, randomized, controlled, double-blinded, cross over study was to compare the level of plaque control and gingivitis after use of a novel dental gel (test) vs. A Triclosan/copolymer dentifrice (control).
After coronal polishing, 22 subjects with moderate gingivitis were randomly assigned to brush twice daily with test or control dentifrice for the first study Arm. Plaque, gingival and sulcus bleeding indices were recorded at baseline, week 2 and week 4. Professional coronal polishing was repeated, and then subjects brushed with the second dentifrice for 4 weeks. Clinical indices were again recorded at Baseline, week 2 and week 4. The effects of each dentifrice on clinical indices were compared using Student's t-test.
Brushing with the test gel produced significantly greater levels of plaque reduction versus the Triclosan/copolymer control dentifrice at each time point. 45% less plaque was measured after 4 weeks of test agent use than after control agent use (p<0.000000005). A significant reduction in gingival inflammation from test vs control agent over w\4 weeks was also observed (p=0.000342).
An activated edathamil dental gel formulation provides effective plaque control and reduced gingival inflammation compared to a Triclosan/Co-polymer dental gel. Practical Implications: A novel dental gel formulation that does not contain abrasives, detergents or antimicrobials may provide effective plaque control and support gingival health.
这项前瞻性、随机、对照、双盲、交叉研究的目的是比较使用一种新型牙科凝胶（试验组）与三氯生/共聚物牙膏（对照组）后牙菌斑控制水平和牙龈炎情况。
在进行牙冠抛光后，22名患有中度牙龈炎的受试者被随机分配，在第一个研究阶段每天用试验组或对照组牙膏刷牙两次。在基线、第2周和第4周记录菌斑、牙龈和龈沟出血指数。再次进行专业牙冠抛光，然后受试者使用第二种牙膏刷牙4周。在基线、第2周和第4周再次记录临床指标。使用学生t检验比较每种牙膏对临床指标的影响。
在每个时间点，使用试验组凝胶刷牙比使用三氯生/共聚物对照组牙膏产生的牙菌斑减少水平显著更高。使用试验组制剂4周后测量的牙菌斑比使用对照组制剂后少45%（p<0.000000005）。在4周内，试验组与对照组制剂相比，牙龈炎症也有显著减轻（p=0.000342）。
与三氯生/共聚物牙科凝胶相比，一种活性依地酸钙钠牙科凝胶制剂能有效控制牙菌斑并减轻牙龈炎症。实际意义：一种不含研磨剂、洗涤剂或抗菌剂的新型牙科凝胶制剂可能有效控制牙菌斑并支持牙龈健康。
