来自甘草培养细胞的黄酮类化合物。

Flavonoids from the cultured cells of Glycyrrhiza uralensis.

作者信息

Feng Ke-Ping, Chen Ri-Dao, Li Jian-Hua, Tao Xiao-Yu, Liu Ji-Mei, Zhang Min, Dai Jun-Gui

机构信息

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.

b Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission , Beijing 100050 , China.

出版信息

J Asian Nat Prod Res. 2016;18(3):253-9. doi: 10.1080/10286020.2015.1074573. Epub 2015 Oct 14.

DOI:10.1080/10286020.2015.1074573

PMID:26465203

Abstract

Two new flavonoids (1 and 2), along with 14 known ones (3-16), were isolated from the cultured cells of Glycyrrhiza uralensis. Most of them were prenylated flavonoids. Their structures were elucidated on the basis of spectroscopic data analysis. All compounds showed non-cytotoxicity against five human tumor cell lines. The results suggest that plant cultured cells can yield the secondary metabolites that have not been found in parent plant.

摘要

从甘草的培养细胞中分离出两种新的黄酮类化合物（1和2）以及14种已知化合物（3 - 16）。它们中的大多数是异戊烯基黄酮类化合物。基于光谱数据分析阐明了它们的结构。所有化合物对五种人类肿瘤细胞系均无细胞毒性。结果表明，植物培养细胞能够产生在亲本植物中未发现的次生代谢产物。