Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) http://www.romangroup.mit.edu.
Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12554-61. doi: 10.1002/anie.201503701. Epub 2015 Sep 3.
The use of metalloenzyme-like zeolites as Lewis acid catalysts for C-C bond formation reactions has received increasing attention over the past few years. In particular, the observation of direct aldol condensation reactions enabled by hydrophobic zeolites with isolated framework metal sites has encouraged the development of catalytic approaches for producing chemicals from biomass-derived compounds. The discovery of new Diels-Alder cycloaddition/dehydration routes and experimental and computational studies of Lewis acid catalyzed carbonyl-ene reactions have given a further boost to this rapidly evolving field.
近年来，金属酶样沸石作为路易斯酸催化剂在 C-C 键形成反应中的应用受到了越来越多的关注。特别是，观察到疏水性沸石中孤立骨架金属位能够实现直接羟醛缩合反应，这鼓励了开发从生物质衍生化合物生产化学品的催化方法。新的 Diels-Alder 环加成/脱水反应的发现以及路易斯酸催化羰基-烯烃反应的实验和计算研究，为这一快速发展的领域提供了进一步的推动。
