Fechtig Daniel J, Schmoll Tilman, Grajciar Branislav, Drexler Wolfgang, Leitgeb Rainer A
Opt Lett. 2014 Sep 15;39(18):5333-6. doi: 10.1364/OL.39.005333.
We present a novel medical imaging modality based on optical coherence tomography (OCT) that enables in vivo 3D tomography at acquisition rates up to 1 MHz. Line field parallel swept source interferometric imaging (LPSI) combines line-field swept source OCT with modulation of the interferometric signal in spatial direction for full range imaging. This method enables high speed imaging with cost-effective and commercially available technology. We explain the realization of the LPSI setup, acquisition, and postprocessing and finally demonstrate 3D in vivo imaging of human nail fold. To the best of our knowledge, sensitivity and depth penetration are competitive with respective point scanning OCT methods at a comparable wavelength. Measured maximum sensitivity is 98.5 dB for 100 kHz and 90 dB for 1 MHz. Together with the significantly relaxed technological requirements regarding detection and swept source technology, LPSI might be a promising concept for future diagnostic OCT imaging.
我们展示了一种基于光学相干断层扫描（OCT）的新型医学成像模式，它能够以高达1兆赫兹的采集速率进行体内三维断层扫描。线场平行扫频源干涉成像（LPSI）将线场扫频源OCT与干涉信号在空间方向上的调制相结合，以实现全范围成像。这种方法能够利用经济高效的商用技术进行高速成像。我们解释了LPSI装置的实现、采集和后处理过程，最后展示了人体甲襞的三维体内成像。据我们所知，在可比波长下，其灵敏度和深度穿透能力与相应的点扫描OCT方法具有竞争力。测得的100千赫兹时的最大灵敏度为98.5分贝，1兆赫兹时为90分贝。连同对检测和扫频源技术的显著放宽的技术要求，LPSI可能是未来诊断OCT成像的一个有前景的概念。
