Huber R, Wojtkowski M, Fujimoto James G, Jiang J Y, Cable A E
Opt Express. 2005 Dec 26;13(26):10523-38. doi: 10.1364/opex.13.010523.
We demonstrate high resolution, three-dimensional OCT imaging with a high speed, frequency swept 1300 nm laser source. A new external cavity semiconductor laser design, optimized for application to swept source OCT, is discussed. The design of the laser enables adjustment of an internal spectral filter to change the filter bandwidth and provides a robust bulk optics design. The laser generates ~30 mW instantaneous peak power at an effective 16 kHz sweep rate with a tuning range of ~133 nm full width. In frequency domain reflectometry and OCT applications, 109 dB sensitivity and ~10 microm axial resolution in tissue can be achieved with the swept laser. The high imaging speeds enable three-dimensional OCT imaging, including zone focusing or C-mode imaging and image fusion to acquire large depth of field data sets with high resolution. In addition, three-dimensional OCT data provides coherence gated en face images similar to optical coherence microscopy (OCM) and also enables the generation of images similar to confocal microscopy by summing signals in the axial direction. High speed, three-dimensional OCT imaging can provide comprehensive data which combines the advantages of optical coherence tomography and microscopy in a single system.
我们展示了使用高速、扫频1300 nm激光源的高分辨率三维光学相干断层扫描（OCT）成像。讨论了一种针对扫频源OCT应用进行优化的新型外腔半导体激光器设计。该激光器的设计能够调整内部光谱滤波器以改变滤波器带宽，并提供坚固的体光学设计。该激光器在有效扫频速率为16 kHz时产生约30 mW的瞬时峰值功率，调谐范围为全宽约133 nm。在频域反射测量和OCT应用中，使用该扫频激光器可在组织中实现109 dB的灵敏度和约10微米的轴向分辨率。高成像速度实现了三维OCT成像，包括区域聚焦或C模式成像以及图像融合，以获取具有高分辨率的大景深数据集。此外，三维OCT数据提供了类似于光学相干显微镜（OCM）的相干选通表面图像，并且还能够通过在轴向方向上对信号求和来生成类似于共聚焦显微镜的图像。高速三维OCT成像可以提供综合数据，在单个系统中结合了光学相干断层扫描和显微镜的优点。
