Osley M A, Newton A
Proc Natl Acad Sci U S A. 1977 Jan;74(1):124-8. doi: 10.1073/pnas.74.1.124.
The relationship between the cell cycle and control of development has been studied by a genetic analysis of Caulobacter crescentus. The behavior of conditional cell division mutants showed that cell cycle events, such as DNA replication and cell division, are organized into a dependent pathway(s), i.e., later steps cannot preceed until earlier ones are completed. The ability of these strains to develop normally under nonpermissive conditions suggested that flagellin synthesis and stalk formation are dependent on the completion of different cell-cycle steps: the periodicity of flagellin synthesis is achieved by coupling it to either DNA chain elongation or completion, and stalk formation is dependent on a later step in the cell-division pathway. These developmental events are not themselves required for cell division, however.
通过对新月柄杆菌的遗传分析，研究了细胞周期与发育控制之间的关系。条件性细胞分裂突变体的行为表明，诸如DNA复制和细胞分裂等细胞周期事件被组织成一条依赖途径，即后续步骤在早期步骤完成之前无法进行。这些菌株在非允许条件下正常发育的能力表明，鞭毛蛋白合成和柄形成依赖于不同细胞周期步骤的完成：鞭毛蛋白合成的周期性是通过将其与DNA链延伸或完成相耦合来实现的，而柄形成则依赖于细胞分裂途径中的后续步骤。然而，这些发育事件本身并非细胞分裂所必需。
