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构建于含柱[5]芳烃的[2]轮烷支架上的生物活性杂糖簇。

Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold.

作者信息

Vincent Stéphane P, Buffet Kevin, Nierengarten Iwona, Imberty Anne, Nierengarten Jean-François

机构信息

University of Namur (UNamur), Académie Louvain, Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, 5000 Namur (Belgium).

Laboratoire de Chimie des Matériaux Moléculaires, Université de Strasbourg et CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg Cedex 2 (France).

出版信息

Chemistry. 2016 Jan 4;22(1):88-92. doi: 10.1002/chem.201504110. Epub 2015 Nov 3.

DOI:10.1002/chem.201504110
PMID:26467313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4832831/
Abstract

A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self-assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa.

摘要

一种合成方法将用于制备多功能纳米分子的最新概念（在多功能支架上进行点击化学）与超分子化学（自组装制备轮烷）相结合，使得能够轻松获得多种复杂的[2]轮烷杂糖簇。具体而言，已制备出结合半乳糖和岩藻糖的化合物，以靶向机会致病菌铜绿假单胞菌的两种细菌凝集素（LecA和LecB）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e587/4832831/077e4ff07739/CHEM-22-88-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e587/4832831/f69789820381/CHEM-22-88-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e587/4832831/0a84c6410805/CHEM-22-88-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e587/4832831/077e4ff07739/CHEM-22-88-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e587/4832831/f69789820381/CHEM-22-88-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e587/4832831/0a84c6410805/CHEM-22-88-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e587/4832831/077e4ff07739/CHEM-22-88-g001.jpg

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