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岩藻糖基富勒烯作为两种细菌凝集素RSL和LecB的紧密配体。

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins.

作者信息

Buffet Kevin, Gillon Emilie, Holler Michel, Nierengarten Jean-François, Imberty Anne, Vincent Stéphane P

机构信息

University of Namur (UNamur), Académie Louvain, Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, B-5000 Namur, Belgium.

出版信息

Org Biomol Chem. 2015 Jun 21;13(23):6482-92. doi: 10.1039/c5ob00689a. Epub 2015 May 13.

DOI:10.1039/c5ob00689a
PMID:25967393
Abstract

A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.

摘要

已经制备了一系列含有多达24个岩藻糖残基的水溶性糖基富勒烯。这些化合物针对两种细菌岩藻糖结合凝集素LecB和RSL进行了测试，带有24个岩藻糖残基的C60(E)12似乎是迄今为止已知的对这两种凝集素的最佳抑制剂。我们已经表明，增加中心核与外围糖之间的间隔基的价数和长度都可能有利于亲和力。

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