Golfieri Rita, Mosconi Cristina, Cappelli Alberta, Giampalma Emanuela, Galaverni Maria Cristina, Pettinato Cinzia, Renzulli Matteo, Monari Fabio, Angelelli Bruna, Pini Patrizia, Terzi Eleonora, Ascanio Salvatore, Garzillo Giorgio, Piscaglia Fabio, Bolondi Luigi, Trevisani Franco
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
Medical Physics Unit, Radiology Unit, S Orsola-Malpighi Hospital, Bologna, Italy.
Future Oncol. 2015;11(23):3133-42. doi: 10.2217/fon.15.267. Epub 2015 Oct 15.
We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC).
Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated.
Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS.
A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
我们根据中晚期肝细胞癌（HCC）的宏观生长模式（结节状与浸润性）和血管侵犯情况，分析了放射性栓塞后的总生存期（OS）。
2005年9月至2013年11月期间，对104例患者进行了治疗（50.0%存在门静脉血栓形成[PVT]，29.8%为浸润性形态）。
节段性与叶性或主干PVT患者的中位OS存在显著差异（p = 0.031），但血管通畅和节段性PVT患者的中位OS均为17个月。浸润性和结节性HCC的中位OS无差异。3个月时有治疗反应的患者中位OS延长（p = 0.023）。既往经动脉化疗栓塞（TACE）也是OS改善的显著预测因素。
放射性栓塞的另一适应证可能是浸润性HCC，因为其OS与结节型相似。
