Hosseini Azar, Mousavi Seyed Hamed, Ghanbari Anis, Homaee Shandiz Fatemeh, Raziee Hamid Reza, Pezeshki Rad Masoud, Mousavi Seyed Hadi
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna J Phytomed. 2015 Sep-Oct;5(5):434-40.
Cancer represents the second cause of mortality in the world. Saffron as a medicinal plant is known for its anti-cancer and anti-depressant properties. In this randomized double blind clinical trial, the effects of saffron on response to treatment in patients suffering from liver metastasis were evaluated.
Thirteen patients suffering from liver metastases who referred to Ghaem and Imam Reza hospital, Mashhad, Iran were included in this study and then divided into two different groups. Both groups received chemotherapy regimen. Patients in group one were treated with saffron capsule (50 mg, twice daily) during chemotherapy periods whereas patients in group two received placebo. A sum of the longest diameter were calculated and compared for all lesions in IV contrast CT scan before and after the treatment.
from 13 patients included in this study, six patients quit and seven continued until the end. In saffron-treated group, two patients showed partial and complete response (50%) whereas in placebo group, no response was seen. Also, two deaths in placebo and one in saffron group occurred.
This research suggests that saffron might be useful in patients suffering from liver metastasis. However, further investigations with larger sample size are required.
癌症是全球第二大致死原因。藏红花作为一种药用植物，以其抗癌和抗抑郁特性而闻名。在这项随机双盲临床试验中，评估了藏红花对肝转移患者治疗反应的影响。
本研究纳入了13例转诊至伊朗马什哈德的加姆医院和伊玛目礼萨医院的肝转移患者，然后将其分为两个不同的组。两组均接受化疗方案。第一组患者在化疗期间接受藏红花胶囊治疗（50毫克，每日两次），而第二组患者接受安慰剂治疗。在治疗前后的静脉对比增强CT扫描中，计算并比较所有病灶的最长直径总和。
本研究纳入的13例患者中，6例退出，7例持续到研究结束。在藏红花治疗组中，2例患者显示部分缓解和完全缓解（50%），而在安慰剂组中未观察到缓解。此外，安慰剂组有2例死亡，藏红花组有1例死亡。
本研究表明，藏红花可能对肝转移患者有用。然而，需要进行更大样本量的进一步研究。
