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磁等离子体纳米杂化物能否有效地将光热疗法与磁热疗法相结合?

Can magneto-plasmonic nanohybrids efficiently combine photothermia with magnetic hyperthermia?

作者信息

Espinosa Ana, Bugnet Mathieu, Radtke Guillaume, Neveu Sophie, Botton Gianluigi A, Wilhelm Claire, Abou-Hassan Ali

机构信息

Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, CNRS and Université Paris Diderot, 75205 Paris cedex 13, France.

出版信息

Nanoscale. 2015 Dec 7;7(45):18872-7. doi: 10.1039/c5nr06168g. Epub 2015 Oct 15.

Abstract

Multifunctional hybrid-design nanomaterials appear to be a promising route to meet the current therapeutics needs required for efficient cancer treatment. Herein, two efficient heat nano-generators were combined into a multifunctional single nanohybrid (a multi-core iron oxide nanoparticle optimized for magnetic hyperthermia, and a gold branched shell with tunable plasmonic properties in the NIR region, for photothermal therapy) which impressively enhanced heat generation, in suspension or in vivo in tumours, opening up exciting new therapeutic perspectives.

摘要

多功能混合设计纳米材料似乎是满足当前高效癌症治疗所需治疗需求的一条有前途的途径。在此,两种高效的热纳米发生器被组合成一种多功能单一纳米杂化物(一种针对磁热疗优化的多核氧化铁纳米颗粒,以及一种在近红外区域具有可调谐等离子体特性的金分支壳,用于光热疗法),该杂化物在悬浮液或肿瘤体内显著增强了发热,开辟了令人兴奋的新治疗前景。

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