β-内啡肽：体内生长激素释放的刺激作用。
Beta-endorphin: stimulation of growth hormone release in vivo.
作者信息
Dupont A, Cusan L, Garon M, Labrie F, Li C H
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):358-9. doi: 10.1073/pnas.74.1.358.
Abstract
Two micrograms of beta-endorphin (beta-lipotropin61-91) injected intraventricularly in rats that had been treated with antiserum against somatostatin led to a 6- and 10-fold stimulation of the concentration of plasma growth hormone (somatotropin) measured 10 and 20 min after injection of the peptide, whereas 400 mug of methionine-enkephalin led to a 4- to 6-fold increase of levels of plasma growth hormone at 10 min with a rapid return to basal levels at later time intervals. At doses of 5 and 25 mug, beta-endorphin led to a 20- to 30-fold stimulation of levels of plasma growth hormone, the maximal effect being measured between 20 and 30 min after injection. These data suggest the possible role of the endogenous opiate-like peptides in the control of growth hormone secretion.
摘要
给用抗生长抑素抗血清处理过的大鼠脑室内注射两微克β-内啡肽（β-促脂素61-91），在注射该肽后10分钟和20分钟时，测得血浆生长激素（促生长素）浓度分别受到6倍和10倍的刺激，而400微克甲硫氨酸脑啡肽在10分钟时可使血浆生长激素水平增加4至6倍，在随后的时间间隔内迅速恢复到基础水平。在5微克和25微克的剂量下，β-内啡肽可使血浆生长激素水平受到20至30倍的刺激，最大效应在注射后20至30分钟测得。这些数据表明内源性阿片样肽在生长激素分泌控制中可能发挥的作用。
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