Chiodera P, Volpi R, Coiro V, Barilli L, Rossi G, Roti E
J Endocrinol Invest. 1983 Oct;6(5):381-4. doi: 10.1007/BF03347621.
To evaluate the interaction between opioid peptides and GABAergic system in regulating GH secretion we administered 5 mg of baclofen, a GABA derivative, to eight normal male subjects. The results were compared to those obtained in the same subjects treated with naloxone (10 mg/2 h) plus baclofen. GH levels increased significantly above basal value either after baclofen and naloxone plus baclofen without any significant difference between GH responses during the two tests. It is suggested that the two substances do not act at the level of the same receptor site. The evaluation of a possible interaction between opioid peptides and GABAergic system on GH release requires further investigation.
为了评估阿片肽与γ-氨基丁酸（GABA）能系统在调节生长激素（GH）分泌中的相互作用，我们给8名正常男性受试者服用了5毫克巴氯芬（一种GABA衍生物）。将结果与用纳洛酮（10毫克/2小时）加巴氯芬治疗的同一受试者所获得的结果进行比较。巴氯芬和纳洛酮加巴氯芬治疗后，GH水平均显著高于基础值，两次测试期间GH反应无显著差异。提示这两种物质并非作用于同一受体位点。关于阿片肽与GABA能系统对GH释放可能存在的相互作用的评估需要进一步研究。
