环丙沙星的临床经验：一项多中心研究的分析

Clinical experience with ciprofloxacin: analysis of a multicenter study.

作者信息

Simmons J F, Cowley C E, Dozier D B, Galdini A M, Manes M R, Nungester G H, Schreeder M T, Strother K D, Chun B W

出版信息

Ala Med. 1989 Feb;58(8):10-3.

Abstract

In a multicenter study of 128 patients treated with ciprofloxacin (mean daily dosage, 982 mg per day; mean duration of treatment, 8.9 days) for a variety of infections, 48 were microbiologically proven. Of these, bacteriologic cure and/or improvement resulted in 93% of cases. For all 128 infections clinical cure and/or improvement resulted in 93.8% of cases. Twenty-nine (23.8%) of all infections were classified as chronic. Overall, there were 3/128 (2.3%) adverse reactions (ADRs); one case each of diarrhea, malaise, and nausea/vomiting. None were related definitely to ciprofloxacin therapy. Therapy with ciprofloxacin was discontinued in two (1.6%) of 128 patients because of adverse gastrointestinal (GI) effects. One patient elected to continue ciprofloxacin therapy despite mild GI side effects.

摘要

在一项多中心研究中，128例因各种感染接受环丙沙星治疗（平均每日剂量982毫克/天；平均治疗持续时间8.9天）的患者中，48例经微生物学证实感染。其中，93%的病例实现了细菌学治愈和/或改善。在所有128例感染中，93.8%的病例实现了临床治愈和/或改善。所有感染中有29例（23.8%）被归类为慢性感染。总体而言，有3/128（2.3%）例出现不良反应（ADR）；分别为腹泻、不适和恶心/呕吐各1例。均与环丙沙星治疗无明确关联。128例患者中有2例（1.6%）因胃肠道（GI）不良反应而停用环丙沙星治疗。1例患者尽管有轻度胃肠道副作用仍选择继续环丙沙星治疗。