环丙沙星的临床经验：一项多中心研究的分析
Clinical experience with ciprofloxacin: analysis of a multicenter study.
作者信息
Hines C H, Bordelon J Y, Jens D K, Le C V, McManus L J, Spurlock W M
出版信息
J La State Med Soc. 1989 Dec;141(12):39-42.
In a multicenter study of 90 patients treated with ciprofloxacin (mean daily dosage, 936 mg per day; mean duration of treatment, 9.7 days) for a variety of infections, 42 were microbiologically proven. For one case the outcome of therapy was unknown. Of the 41 reported outcomes bacteriologic cure resulted in 92.7%, improvement in 7.3% of cases. Clinical cure equaled 88.4%, while improvement was 9.3%. Failure was reported in 2.3% of cases. A total of 14 infections were classified as chronic. Overall, there were 9/90 (10%) adverse reactions. Six were classified as definitely related to therapy. Therapy with ciprofloxacin was discontinued in four (4.4%) patients because of adverse effects.
在一项多中心研究中，90例因各种感染接受环丙沙星治疗的患者（平均每日剂量为936毫克/天；平均治疗持续时间为9.7天），其中42例经微生物学证实。有1例治疗结果未知。在报告的41例结果中，细菌学治愈的占92.7%，病情改善的占7.3%。临床治愈的占88.4%，病情改善的占9.3%。报告有2.3%的病例治疗失败。共有14例感染被归类为慢性感染。总体而言，90例中有9例（10%）出现不良反应。其中6例被明确归类为与治疗有关。4例（4.4%）患者因不良反应而停用环丙沙星治疗。
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