Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, P.T.S., Granada, Spain.
Clínica de Falla Cardíaca y Trasplante, Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia.
Genes Immun. 2015 Dec;16(8):536-40. doi: 10.1038/gene.2015.42. Epub 2015 Oct 15.
Human host genetic factors have been suggested to be determinants of the prevalence and clinical forms of Chagas disease. In this regard, IL-17A is believed to control parasitemia and protect against heart disease. In this work, we assessed whether IL17A gene polymorphisms are related to infection and/or development of the cardiac form of Chagas disease by genotyping for five IL17A SNPs (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) in 1171 individuals from a Colombian region endemic for Chagas disease, classified as seronegative (n=595), seropositive asymptomatic (n=175) and chronic Chagas cardiomyopathy (n=401). Our results showed that SNP rs8193036, which is located upstream of the coding region of the gene, was slightly associated with protection against T. cruzi infection (P=0.0170, P(FDR)=0.0851, odds ratio (OR)=0.80, confidence interval (CI)=0.66-0.96) and associated with protection against the development of cardiomyopathy (P=0.0065, P(FDR)=0.0324, OR=0.75, CI=0.60-0.92). This finding suggests that this IL17A polymorphism could be associated with Trypanosoma cruzi infection and the development of chronic cardiomyopathy due to differential expression of cytokine IL-17A.
宿主遗传因素被认为是影响恰加斯病流行和临床形式的决定因素。在这方面，IL-17A 被认为可以控制寄生虫血症并预防心脏病。在这项工作中，我们通过对来自哥伦比亚恰加斯病流行地区的 1171 个人的五个 IL17A SNPs（rs4711998、rs8193036、rs3819024、rs2275913 和 rs7747909）进行基因分型，评估了 IL17A 基因多态性是否与感染和/或恰加斯病心脏形式的发展有关，这些人被分类为血清阴性（n=595）、血清阳性无症状（n=175）和慢性恰加斯心肌病（n=401）。我们的结果表明，位于基因编码区上游的 SNP rs8193036 与对 T. cruzi 感染的保护作用略有相关（P=0.0170，P(FDR)=0.0851，比值比（OR）=0.80，置信区间（CI）=0.66-0.96），并且与心肌病的发展相关（P=0.0065，P(FDR)=0.0324，OR=0.75，CI=0.60-0.92）。这一发现表明，这种 IL17A 多态性可能与 T. cruzi 感染和慢性心肌病的发展有关，这是由于细胞因子 IL-17A 的差异表达所致。
