Simsek Gokce, Haytoglu Suheyl, Muluk Nuray Bayar, Arikan Osman Kursat, Cortuk Mustafa, Kiraz Kemal
*ENT Department, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey †ENT Clinic, Adana Numune Training and Research Hospital, Adana, Turkey ‡Chest Diseases Clinic, Adana Numune Training and Research Hospital, Adana, Turkey §Chest Diseases Clinic, Antalya Training and Research Hospital, Antalya, Turkey.
J Craniofac Surg. 2015 Oct;26(7):2152-4. doi: 10.1097/SCS.0000000000001954.
The main purpose of the study was to investigate changes in mean platelet volume (MPV) values in patients with obstructive sleep apnea syndrome (OSAS) who had undergone uvulopalatal flap (UPF) surgery.
The study included a review of the medical records of 37 adult patients who had undergone UPF surgery after being diagnosed with OSAS. The baseline blood parameters of patients, including the MPV and platelet distribution width (PDW) values, were measured and repeated 3 months after treatment. Polysomnographic evaluations of the patients were also performed during admission and the 3rd month control. Comparisons of MPV values and their correlation with polysomnographic parameters were the main outcomes measured.
The blood parameters of all patients were similar except for MPV values, which were significantly lower after treatment (P < 0.001). Patients' apnea hypopnea index (AHI) and apnea episodes were significantly reduced after the UPF surgery, whereas their oxygen saturation significantly increased (P < 0.001). The MPV values were not correlated with polysomnographic parameters (P > 0.05).
The UPF surgery, which is a relatively simple surgical intervention to treat OSAS, alleviates nocturnal hypoxic episodes and lowers platelet volume. These may both be important predictors of adverse cardiovascular outcomes related to OSAS.
本研究的主要目的是调查接受悬雍垂腭瓣（UPF）手术的阻塞性睡眠呼吸暂停综合征（OSAS）患者的平均血小板体积（MPV）值的变化。
该研究回顾了37例经诊断为OSAS后接受UPF手术的成年患者的病历。测量患者的基线血液参数，包括MPV和血小板分布宽度（PDW）值，并在治疗后3个月重复测量。在入院时和第3个月复查时也对患者进行了多导睡眠图评估。主要测量指标为MPV值的比较及其与多导睡眠图参数的相关性。
除MPV值外，所有患者的血液参数相似，治疗后MPV值显著降低（P < 0.001）。UPF手术后患者的呼吸暂停低通气指数（AHI）和呼吸暂停发作次数显著减少，而血氧饱和度显著增加（P < 0.001）。MPV值与多导睡眠图参数无相关性（P > 0.05）。
UPF手术是一种治疗OSAS的相对简单的手术干预措施，可减轻夜间缺氧发作并降低血小板体积。这些可能都是与OSAS相关的不良心血管结局的重要预测指标。
