复发性阿弗他口炎患者中性粒细胞、淋巴细胞和血小板的状态：一项回顾性研究
Status of Neutrophils, Lymphocytes and Platelets in Patients with Recurrent Aphthous Stomatitis: A Retrospective Study.
作者信息
Terzi Suat, Dursun Engin, Özgür Abdulkadir, Yiğit Enes, Özergin-Coşkun Zerrin, Çelebi-Erdivanl Özlem, Demirci Münir
机构信息
Department of Otorhinolaryngology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey.
出版信息
Iran J Otorhinolaryngol. 2016 Nov;28(89):421-424.
Abstract
INTRODUCTION
The aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in patients with recurrent aphthous stomatitis (RAS).
MATERIALS AND METHODS
Eighty patients who were diagnosed with RAS between January 2014 and January 2016 were included in this study. Eighty age- and gender-matched healthy subjects were also enrolled as a control group. Neutrophil, lymphocyte, and platelet counts were compared between groups, in addition to NLR, PLR, and MPV values.
RESULTS
There was no significant difference in terms of lymphocyte count, platelet count, PLR, or MPV values between the two groups (P>0.05). However, white blood count, neutrophil count, and NLR were significantly higher in patients with RAS compared with the control group (P<0.05).
CONCLUSION
The present study revealed an increased NLR among RAS patients compared with healthy controls. This suggests that development of RAS involves an inflammatory process. We believe that NLR could be used as a cheap and simple marker of inflammation.
摘要
引言
本研究的目的是评估复发性阿弗他口炎（RAS）患者的中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及平均血小板体积（MPV）。
材料与方法
本研究纳入了2014年1月至2016年1月期间诊断为RAS的80例患者。另外选取80例年龄和性别匹配的健康受试者作为对照组。比较两组之间的中性粒细胞、淋巴细胞和血小板计数，以及NLR、PLR和MPV值。
结果
两组之间的淋巴细胞计数、血小板计数、PLR或MPV值无显著差异（P>0.05）。然而，与对照组相比，RAS患者的白细胞计数、中性粒细胞计数和NLR显著更高（P<0.05）。
结论
本研究显示，与健康对照组相比，RAS患者的NLR升高。这表明RAS的发生涉及炎症过程。我们认为NLR可作为一种廉价且简单的炎症标志物。
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3
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J Craniofac Surg. 2015 Oct;26(7):2152-4. doi: 10.1097/SCS.0000000000001954.
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