为精准医学中的基因组学奠定基础。
Building the foundation for genomics in precision medicine.
作者信息
Aronson Samuel J, Rehm Heidi L
机构信息
Partners HealthCare Personalized Medicine, Boston, Massachusetts 02115, USA.
Partners HealthCare Research Information Services and Computing, Charlestown, Massachusetts 02129, USA.
出版信息
Nature. 2015 Oct 15;526(7573):336-42. doi: 10.1038/nature15816.
Abstract
Precision medicine has the potential to profoundly improve the practice of medicine. However, the advances required will take time to implement. Genetics is already being used to direct clinical decision-making and its contribution is likely to increase. To accelerate these advances, fundamental changes are needed in the infrastructure and mechanisms for data collection, storage and sharing. This will create a continuously learning health-care system with seamless cycling between clinical care and research. Patients must be educated about the benefits of sharing data. The building blocks for such a system are already forming and they will accelerate the adoption of precision medicine.
摘要
精准医学有潜力极大地改善医疗实践。然而，所需的进展实施起来需要时间。遗传学已被用于指导临床决策，其贡献可能会增加。为了加速这些进展，数据收集、存储和共享的基础设施及机制需要进行根本性变革。这将创建一个持续学习的医疗保健系统，使临床护理和研究之间实现无缝循环。必须让患者了解数据共享的益处。这样一个系统的基础已经在形成，它们将加速精准医学的应用。
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