为期8周的剧烈自行车运动能否改善2型糖尿病患者及代谢综合征高危个体中与糖尿病相关的炎性细胞因子和游离脂肪酸水平？

Does 8 weeks of strenuous bicycle exercise improve diabetes-related inflammatory cytokines and free fatty acids in type 2 diabetes patients and individuals at high-risk of metabolic syndrome?

作者信息

Madsen Søren Møller, Thorup Anne Cathrine, Bjerre Mette, Jeppesen Per Bendix

机构信息

a Department of Endocrinology and Internal Medicine , Aarhus Sygehus THG, Aarhus University Hospital , Aarhus C , Denmark and.

b The Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University , Denmark .

出版信息

Arch Physiol Biochem. 2015;121(4):129-38. doi: 10.3109/13813455.2015.1082600.

DOI:10.3109/13813455.2015.1082600

PMID:26469542

Abstract

UNLABELLED

In the present study, the effects of 8 weeks of low volume high intensity interval training (HIIT) was investigated on circulating diabetes-related cytokines and free fatty acids (FFA) in adults with type 2 diabetes (T2D) and matched controls (CON).

METHODS

Participants exercised for 8 weeks (3 weekly sessions: 10 × 60 sec HIIT) on a cycle ergometer supervised by medical staff. Prior to the intervention and after the last HIIT session, venous blood samples were collected.

RESULTS

Circulating omentin-1 concentrations increased significantly in both the CON-group (p = 0.003) and in the T2D-group (p = 0.002). Pentraxin-3 (p = 0.010) and IL-1ra (p = 0.031) levels increased significantly in the CON-group. Plasma FFA in the T2D-group was significantly reduced after 60 min (p = 0.011). Post HIIT area under curve of circulating FFAs was reduced by -17.73 ± 6.99% (p = 0.041) in the T2D-group.

CONCLUSION

We observed only modest exercise-induced improvements of multiple diabetes-related cytokines. Circulating levels of FFAs were significantly lowered in the T2D-group.

摘要

未标注

在本研究中，调查了为期8周的小运动量高强度间歇训练（HIIT）对2型糖尿病（T2D）成人及匹配对照组（CON）循环中糖尿病相关细胞因子和游离脂肪酸（FFA）的影响。

方法

参与者在医务人员监督下于自行车测力计上进行8周锻炼（每周3次：10×60秒HIIT）。在干预前和最后一次HIIT训练后采集静脉血样。

结果

CON组（p = 0.003）和T2D组（p = 0.002）循环中的网膜素-1浓度均显著增加。CON组中五聚体-3（p = 0.010）和白细胞介素-1受体拮抗剂（IL-1ra，p = 0.031）水平显著升高。60分钟后，T2D组血浆FFA显著降低（p = 0.011）。HIIT后，T2D组循环FFA的曲线下面积降低了-17.73±6.99%（p = 0.041）。