Ouerghi Nejmeddine, Ben Fradj Mohamed Kacem, Bezrati Ikram, Feki Moncef, Kaabachi Naziha, Bouassida Anissa
Research Unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia.
Obes Facts. 2017;10(4):323-331. doi: 10.1159/000471882. Epub 2017 Aug 5.
Omentin-1 is a recently discovered adipokine, mainly produced by visceral adipose tissue, which is thought to improve insulin sensitivity. The study aimed to assess the association of plasma omentin-1 with cardiometabolic traits and physical performance and to test its response to high-intensity interval training (HIIT) in obese and normal-weight subjects.
Nine overweight/obese (OG) and 9 normal-weight (NWG) young men performed an 8-week HIIT program. Body composition, physical performance, homeostasis model assessment index for insulin resistance (HOMA-IR) as well as plasma omentin-1and lipid levels were assessed before and after the HIIT program.
Baseline plasma omentin-1 was lower in OG than NWG men (359 ± 138 vs. 470 ± 114 ng/ml; p = 0.052). Plasma omentin-1 was related to body fat (r = -0.57; p = 0.03) and LDL-cholesterol (r = -0.49; p = 0.04). There was a trend towards significant association of omentin-1 with BMI (r = -0.47; p = 0.06) and VO2max (r = 0.41; p = 0.09). However, no association was observed with HOMA-IR. Following the HIIT program, omentin-1 concentrations have significantly (p < 0.01) increased in OG (359 ± 138 to 455 ± 126 ng/ml) and NWG men (470 ± 114 to 572 ± 115 ng/ml). In parallel, the cardiometabolic profile has improved with a significant decrease of HOMA-IR in OG.
HIIT resulted in a plasma omentin-1 increase and an improvement with regard to cardiometabolic traits in the OG men, which may contribute to modulate insulin sensitivity.
网膜素-1是一种最近发现的脂肪因子，主要由内脏脂肪组织产生，被认为可改善胰岛素敏感性。本研究旨在评估血浆网膜素-1与心脏代谢特征及身体机能的关联，并测试肥胖和正常体重受试者对高强度间歇训练（HIIT）的反应。
9名超重/肥胖（OG）和9名正常体重（NWG）的年轻男性进行了为期8周的HIIT计划。在HIIT计划前后评估身体成分、身体机能、胰岛素抵抗的稳态模型评估指数（HOMA-IR）以及血浆网膜素-1和血脂水平。
OG组男性的基线血浆网膜素-1低于NWG组男性（359±138 vs. 470±114 ng/ml；p = 0.052）。血浆网膜素-1与体脂（r = -0.57；p = 0.03）和低密度脂蛋白胆固醇（r = -0.49；p = 0.04）相关。网膜素-1与BMI（r = -0.47；p = 0.06）和最大摄氧量（r = 0.41；p = 0.09）有显著关联的趋势。然而，未观察到与HOMA-IR的关联。HIIT计划后，OG组男性（359±138至455±126 ng/ml）和NWG组男性（470±114至572±115 ng/ml）的网膜素-1浓度显著升高（p < 0.01）。同时，OG组的心脏代谢指标有所改善，HOMA-IR显著降低。
HIIT导致OG组男性血浆网膜素-1增加以及心脏代谢特征改善，这可能有助于调节胰岛素敏感性。
