Chen Qi, Polireddy Kishore, Chen Ping, Dong Ruochen
Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.
Can J Physiol Pharmacol. 2015 Dec;93(12):1055-63. doi: 10.1139/cjpp-2014-0509. Epub 2015 May 27.
Effectiveness and low-toxicity to normal tissues are ideal properties for a cancer treatment, and one that numerous research programs are aiming for. Vitamin C has long been used in the field of Complementary and Alternative Medicine as a cancer treatment, with profound safety and anecdotal efficacy. Recent studies revealed the scientific basis for this use, and indicated that vitamin C, at supra-nutritional doses, holds considerable promise as an effective and low-toxic therapeutic strategy to treat cancer. Reviewed here are the early controversies surrounding vitamin C and cancer treatment, the breakthrough discoveries that led to the current advancement, and recent clinical studies, as well as research into its mechanisms of action.
对癌症治疗而言，有效性以及对正常组织的低毒性是理想特性，也是众多研究项目所追求的目标。长期以来，维生素C一直被用于补充和替代医学领域作为癌症治疗手段，具有较高的安全性且有一定疗效。近期研究揭示了这种应用的科学依据，并表明超营养剂量的维生素C作为一种有效且低毒的癌症治疗策略具有很大潜力。本文回顾了围绕维生素C与癌症治疗的早期争议、促成当前进展的突破性发现、近期的临床研究以及其作用机制的研究。
