在一项HIV-1预防临床试验中，对在孕期或哺乳期发生原发性HIV-1感染的女性快速启动抗逆转录病毒治疗
Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding.
作者信息
Morrison Susan, John-Stewart Grace, Egessa John J, Mubezi Sezi, Kusemererwa Sylvia, Bii Dennis K, Bulya Nulu, Mugume Francis, Campbell James D, Wangisi Jonathan, Bukusi Elizabeth A, Celum Connie, Baeten Jared M
机构信息
Department of Global Health, University of Washington, Seattle, WA, United States of America.
Department of Global Health, University of Washington, Seattle, WA, United States of America; Department of Medicine, University of Washington, Seattle, WA United States of America; Department of Epidemiology, University of Washington, Seattle, United States of America.
出版信息
PLoS One. 2015 Oct 15;10(10):e0140773. doi: 10.1371/journal.pone.0140773. eCollection 2015.
During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.
在东非进行的一项HIV-1预防临床试验中，我们观察到16例女性原发性HIV-1感染病例，这些病例发生在怀孕或哺乳期。11名孕妇中有9人开始接受快速联合抗逆转录病毒治疗（ART），尽管她们的CD4细胞计数超过了国家ART起始标准；哺乳期妇女开始接受ART或采用替代喂养。在这种情况下，在怀孕和哺乳期原发性HIV-1感染期间快速启动ART是可行的。
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