[一株阿留申水貂病病毒VP2基因高变区的测序分析]

[Sequencing Analyses of the Hypervariable Region within the VP2 Gene of a Strain of the Aleutian Mink Disease Virus].

作者信息

Zhang Lei, Hu Bo, Bai Xue, Zhang Hailing, Zhao Jianjun, Wang Zhenjun, Ma Fanshu, Yan Xijun, Wu Wei, Xu Shujuan

出版信息

Bing Du Xue Bao. 2015 May;31(3):226-30.

Abstract

To analyze the molecular mechanisms of cross-host transmission of the Aleutian mink disease vi rus (ADV), the hypervariable region fragment of the VP2 gene of the ADV in Jilin Province (China) was amplified. Sequencing analyses showed diversity at residue 174 by comparison with other VP2 genes in GenBank. The phylogenetic tree indicated that the ADV-JL strain had a close relationship with the highly pathogenic strain from Denmark: ADV-K. Results implied that residue 174 may be associated with ADV infectivity.

摘要

为分析阿留申水貂病病毒（ADV）跨宿主传播的分子机制，扩增了中国吉林省ADV的VP2基因高变区片段。测序分析表明，与GenBank中的其他VP2基因相比，第174位氨基酸存在多样性。系统发育树表明，ADV-JL毒株与来自丹麦的高致病性毒株ADV-K关系密切。结果表明，第174位氨基酸可能与ADV的感染性有关。