Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S8-11. doi: 10.1016/j.jaad.2015.07.045.
The pathogenesis of hidradenitis suppurativa (HS) or acne inversa is not completely understood. Recent research has led to greater insight into the mechanisms involved in the disease. The primary defect in HS pathophysiology rests with the hair follicle. Follicular occlusion, followed by follicular rupture, and a foreign body-type immune response are necessary conditions for the development of clinical HS. A specific genetic signature and environmental factors, such as cigarette smoking, microbial colonization, and adiposity, all contribute to the HS phenotype. Translational research focused on the inflammatory mechanisms involved in HS is needed to develop novel therapeutic options for this debilitating disease.
化脓性汗腺炎（HS）或反向痤疮的发病机制尚不完全清楚。最近的研究使我们对疾病相关机制有了更深入的了解。HS 病理生理学的主要缺陷在于毛囊。毛囊堵塞，随后毛囊破裂，以及异物型免疫反应，是临床 HS 发展的必要条件。特定的遗传特征和环境因素，如吸烟、微生物定植和肥胖，都促成了 HS 的表型。需要针对 HS 涉及的炎症机制进行转化研究，以开发这种使人衰弱的疾病的新治疗选择。
