Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
Institute of Biopharmaceutical Sciences, Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Mar Drugs. 2021 Jan 8;19(1):25. doi: 10.3390/md19010025.
Three new and rare chromone derivatives, epiremisporine C (), epiremisporine D (), and epiremisporine E (), were isolated from marine-derived , together with four known compounds, epiremisporine B (), penicitrinone A (), 8-hydroxy-1-methoxycarbonyl-6-methylxanthone (), and isoconiochaetone C (). Among the isolated compounds, compounds - significantly decreased fMLP-induced superoxide anion generation by human neutrophils, with IC values of 6.39 ± 0.40, 8.28 ± 0.29, 3.62 ± 0.61, and 2.67 ± 0.10 μM, respectively. Compounds and exhibited cytotoxic activities with IC values of 43.82 ± 6.33 and 32.29 ± 4.83 μM, respectively, against non-small lung cancer cell (A549), and Western blot assay confirmed that compounds and markedly induced apoptosis of A549 cells, through Bcl-2, Bax, and caspase 3 cascades.
从海洋来源的真菌中分离得到了三个新的罕见色酮衍生物，即 epiremisporine C ()、epiremisporine D () 和 epiremisporine E ()，以及四个已知化合物，即 epiremisporine B ()、penicitrinone A ()、8-羟基-1-甲氧基羰基-6-甲基黄烷酮 () 和 isoconiochaetone C ()。在分离得到的化合物中，化合物 - 显著抑制人中性粒细胞中 fMLP 诱导的超氧阴离子生成，IC 值分别为 6.39 ± 0.40、8.28 ± 0.29、3.62 ± 0.61 和 2.67 ± 0.10 μM。化合物 和 对非小细胞肺癌细胞 (A549) 表现出细胞毒性活性，IC 值分别为 43.82 ± 6.33 和 32.29 ± 4.83 μM，Western blot 分析证实化合物 和 通过 Bcl-2、Bax 和 caspase 3 级联反应显著诱导 A549 细胞凋亡。
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