Chen Jih-Jung, Luo Yu-Ting, Hwang Tsong-Long, Sung Ping-Jyun, Wang Tai-Chi, Chen Ih-Sheng
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
Chem Biodivers. 2008 Jul;5(7):1345-52. doi: 10.1002/cbdv.200890122.
A new indole alkaloid, 11,12-dimethoxyhenningsamine, was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine and aesculetin dimethyl ether exhibited potent inhibition (IC(50) < 5.5 microg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B.
从华钩藤根中分离出一种新的吲哚生物碱11,12 - 二甲氧基亨宁胺，以及19种已知化合物。通过光谱和质谱分析确定了该新化合物的结构。在分离出的化合物中，11 - 甲氧基亨宁胺和七叶亭二甲醚对人中性粒细胞在fMet - Leu - Phe/细胞松弛素B刺激下产生超氧阴离子和释放弹性蛋白酶表现出强效抑制作用（IC(50) < 5.5微克/毫升）。
