Jiang Feng, Liu Biao, Lu Jun, Li Fangfei, Li Defang, Liang Chao, Dang Lei, Liu Jin, He Bing, Badshah Shaikh Atik, Lu Cheng, He Xiaojuan, Guo Baosheng, Zhang Xiao-Bing, Tan Weihong, Lu Aiping, Zhang Ge
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Hong Kong Baptist University Branch of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University, Hong Kong, China.
Int J Mol Sci. 2015 Oct 9;16(10):23784-822. doi: 10.3390/ijms161023784.
Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.
适体可通过指数富集配体系统进化技术（SELEX）筛选获得，因其具有高选择性和亲和力，是用于分子识别的优异配体。由于其独特优势，将适体用作靶向给药配体的关注度日益增加。基于其不同的组成和制备方法，适体功能化靶向给药系统可主要分为两类：适体-小分子共轭系统和适体-纳米材料共轭系统。在本综述中，我们不仅总结了适体筛选的最新进展以及适体在这些靶向给药系统中的应用，还讨论了与这些给药系统相关的优势、挑战和新观点。
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