Haigh Jodie N, Chuang Ya-Mi, Farrugia Brooke, Hoogenboom Richard, Dalton Paul D, Dargaville Tim R
Nanotechnology and Molecular Science Discipline, Science and Engineering Faculty, Queensland University of Technology, Queensland, 4001, Australia.
Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales, Sydney, 2052, Australia.
Macromol Rapid Commun. 2016 Jan;37(1):93-99. doi: 10.1002/marc.201500495. Epub 2015 Oct 16.
A new method for fabricating hydrogels with intricate control over hierarchical 3D porosity using microfiber porogens is presented. Melt electrospinning writing of poly(ε-caprolactone) is used to create the sacrificial template leading to hierarchical structuring consisting of pores inside the denser poly(2-oxazoline) hydrogel mesh. This versatile approach provides new opportunities to create well-defined multilevel control over interconnected pores with diameters in the lower micrometer range inside hydrogels with potential applications as cell scaffolds with tunable diffusion and transport of, e.g., nutrients, growth factors or therapeutics.
提出了一种利用微纤维致孔剂制造对分级三维孔隙率具有精细控制的水凝胶的新方法。采用聚（ε-己内酯）的熔体静电纺丝书写来创建牺牲模板，从而形成由较致密的聚（2-恶唑啉）水凝胶网内部的孔隙组成的分级结构。这种通用方法为在水凝胶内部创建直径在低微米范围内的相互连接孔隙的明确多级控制提供了新机会，这些水凝胶具有作为细胞支架的潜在应用，可对营养物质、生长因子或治疗剂进行可调扩散和运输。
