Plastic Surgeon, private practice, Zurich, Switzerland; Department of Plastic Surgery, Medical School, Aristotle University of Thessaloniki, Greece.
Unit of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Greece.
Metabolism. 2015 Dec;64(12):1640-9. doi: 10.1016/j.metabol.2015.09.015. Epub 2015 Sep 25.
Adipose tissue is an endocrine organ, which is implicated in the pathogenesis of obesity, metabolic syndrome and diabetes. Lipectomy offers a unique opportunity to permanently reduce the absolute number of fat cells, though its functional role remains unclear. This systematic and meta-analysis review aims to assess the effect of abdominal lipectomy on metabolic syndrome components and insulin sensitivity in women.
A predetermined protocol, established according to the Cochrane Handbook's recommendations, was used. An electronic search in MEDLINE, Scopus, the Cochrane Library and CENTRAL electronic databases was conducted from inception to May 14, 2015. This search was supplemented by a review of reference lists of potentially eligible studies and a manual search of key journals in the field of plastic surgery. Eligible studies were prospective studies with ≥1month of follow-up that included females only who underwent abdominal lipectomy and reported on parameters of metabolic syndrome and insulin sensitivity.
The systematic review included 11 studies with a total of 271 individuals. Conflicting results were revealed, though most studies showed no significant metabolic effects after lipectomy. The meta-analysis included 4 studies with 140 subjects. No significant changes were revealed between lipectomy and control groups.
This meta-analysis provides evidence that abdominal lipectomy in females does not affect significantly the components of metabolic syndrome and insulin sensitivity. Further high quality studies are needed to elucidate the potential metabolic effects of abdominal lipectomy. Systematic review registration PROSPERO CRD42015017564 (www.crd.york.ac.uk/PROSPERO).
脂肪组织是一种内分泌器官，它与肥胖症、代谢综合征和糖尿病的发病机制有关。脂肪切除术为永久性减少脂肪细胞的绝对数量提供了一个独特的机会，尽管其功能作用尚不清楚。本系统评价和荟萃分析旨在评估腹部脂肪切除术对女性代谢综合征成分和胰岛素敏感性的影响。
根据 Cochrane 手册的建议制定了预定的方案。从成立到 2015 年 5 月 14 日，在 MEDLINE、Scopus、Cochrane 图书馆和 CENTRAL 电子数据库中进行了电子搜索。通过对潜在合格研究的参考文献列表进行审查以及对整形外科学领域的主要期刊进行手动搜索，对该搜索进行了补充。合格的研究是前瞻性研究，随访时间≥1 个月，仅包括接受腹部脂肪切除术并报告代谢综合征和胰岛素敏感性参数的女性。
系统评价纳入了 11 项研究，共 271 人。尽管大多数研究表明脂肪切除术后代谢无明显变化，但结果存在矛盾。荟萃分析纳入了 4 项研究，共 140 名受试者。脂肪切除术组和对照组之间未发现显著变化。
本荟萃分析提供的证据表明，女性腹部脂肪切除术不会显著影响代谢综合征和胰岛素敏感性的成分。需要进一步进行高质量的研究，以阐明腹部脂肪切除术的潜在代谢作用。系统评价注册 PROSPERO CRD42015017564（www.crd.york.ac.uk/PROSPERO）。
