Song Jin-Tong, Han Yang, Wang Xiao-Ling, Shen Tao, Lou Hong-Xiang, Wang Xiao-Ning
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
The Second Hospital of Shandong University, 247 Bei-Yuan Street, Jinan 250033, PR China.
Fitoterapia. 2015 Dec;107:54-59. doi: 10.1016/j.fitote.2015.10.006. Epub 2015 Oct 22.
One new 9,10-seco-abietane derivative, crotontomentosin A (1), four new abietane-type diterpenoids, crotontomentosins B-E (2-5), one new ent-halimane-type diterpenoid, crotontomentosin F (6), along with five known diterpenoids (7-11) and one known sesquiterpenoid (12) were obtained from the twigs and leaves of Croton caudatus Geisel. var. tomentosus Hook. The structures of the compounds were established on the basis of extensive spectroscopic data. Compounds 1-4 and 11 exhibited moderate to weak inhibitory activity against the proliferation of the Hela, Hep G2, MDA-MB-231, or A549 cell lines selectively.
从尾叶巴豆（Croton caudatus Geisel. var. tomentosus Hook.）的嫩枝和叶子中得到了一种新的9,10-断松香烷衍生物巴豆绒毛素A（1）、四种新的松香烷型二萜巴豆绒毛素B - E（2 - 5）、一种新的对映-海松烷型二萜巴豆绒毛素F（6），以及五种已知的二萜（7 - 11）和一种已知的倍半萜（12）。通过广泛的光谱数据确定了这些化合物的结构。化合物1 - 4和11对Hela、Hep G2、MDA - MB - 231或A549细胞系的增殖表现出中等至较弱的选择性抑制活性。
