Lademann J, Richter H, Schanzer S, Meinke M C, Darvin M E, Schleusener J, Carrer V, Breuckmann P, Patzelt A
Charité - Universitätsmedizin Berlin, Klinik für Dermatologie, Venerologie und Allergologie, Hautphysiologie, Charitéplatz 1, 10117, Berlin, Deutschland.
Institut für Angewandte Chemie Katalonien, Bereich für Chemische Technologien, Jordi Girona 18-26, 08034, Barcelona, Spanien.
Hautarzt. 2019 Mar;70(3):185-192. doi: 10.1007/s00105-018-4343-y.
The hair follicle represents a significant penetration route for topically applied substances.
The percutaneous absorption of substances can be significantly increased and accelerated by the involvement of hair follicles. In addition, nanoparticles have the characteristic to penetrate deeply and effectively into the hair follicles.
An optimization of drug delivery for topically applied substances is possible if the nanoparticles act solely as a carrier to transport active ingredients into the hair follicle. Once the nanocarrier has penetrated into the hair follicle, the active substance must be released there. This can be triggered by various mechanisms.
The released drug can thus pass into the living tissue surrounding the hair follicle independently. With the help of this innovative strategy, the bioavailability of topically applied substances can be significantly improved.
The transport of active ingredients into the hair follicles with the help of particles and the release of active substances there is a very effective new method for transporting active substances through the skin barrier.
毛囊是局部应用物质的重要渗透途径。
毛囊的参与可显著增加和加速物质的经皮吸收。此外，纳米颗粒具有深入且有效地渗透到毛囊中的特性。
如果纳米颗粒仅作为将活性成分运输到毛囊中的载体，那么局部应用物质的药物递送优化是可行的。一旦纳米载体渗透到毛囊中，活性物质必须在那里释放。这可由多种机制触发。
释放的药物因此可独立进入毛囊周围的活组织。借助这种创新策略，局部应用物质的生物利用度可显著提高。
借助颗粒将活性成分运输到毛囊中并在那里释放活性物质是一种通过皮肤屏障运输活性物质的非常有效的新方法。
