Hassanzadeh-Tabrizi S A, Bigham Ashkan, Rafienia Mohammad
Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran.
Advanced Materials Research Center, Materials Engineering Department, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran.
Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:737-41. doi: 10.1016/j.msec.2015.09.020. Epub 2015 Sep 5.
In the present study, forsterite nanoparticles were synthesized via surfactant-assisted sol-gel method using cetyltrimethyl ammonium bromide (CTAB) as a surfactant. The effects of CTAB contents and heat treatment on the textural properties and drug release from nanoparticles were investigated. The synthesized powders were studied by X-ray diffraction, Fourier transform infrared spectra, Brunauer-Emmett-Teller surface area analysis and transmission electron microscope images. Mg2SiO4 materials demonstrated mesoporous characteristics and large specific surface area ranging from 159 to 30 m(2)/g. The TEM results showed that forsterite nanorods had diameters about 4 nm and lengths ranging from 10 to 60 nm. It was found that the samples with 6g CTAB show slower drug release rate than the other specimens, which is due to smaller pore size. This study revealed that the drug delivery of forsterite can be tailored by changing the amount of surfactant.
在本研究中，以十六烷基三甲基溴化铵（CTAB）为表面活性剂，通过表面活性剂辅助溶胶 - 凝胶法合成了镁橄榄石纳米颗粒。研究了CTAB含量和热处理对纳米颗粒的织构性质及药物释放的影响。通过X射线衍射、傅里叶变换红外光谱、布鲁诺尔 - 埃米特 - 泰勒比表面积分析和透射电子显微镜图像对合成的粉末进行了研究。Mg2SiO4材料表现出介孔特性，比表面积大，范围为159至30 m(2)/g。透射电子显微镜结果表明，镁橄榄石纳米棒的直径约为4 nm，长度范围为10至60 nm。发现含有6g CTAB的样品比其他样品的药物释放速率慢，这是由于孔径较小。该研究表明，通过改变表面活性剂的用量可以调整镁橄榄石的药物递送。
