Zargar Seyed Mohammad, Hafshejani Darioush Khodabakhshi, Eskandarinia Asghar, Rafienia Mohamad, Kharazi Anousheh Zargar
Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.
Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Medical Technologies, Isfahan University of Medical Sciences, Isfahan, Iran.
J Med Signals Sens. 2019 Aug 29;9(3):181-189. doi: 10.4103/jmss.JMSS_53_18. eCollection 2019 Jul-Sep.
Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article.
新型药物递送系统改善了药物的药代动力学，减少了不良影响，同时通过延长释放时间提高了患者的依从性。事实上，尽管在药物控释方面取得了许多令人鼓舞的成就，但微米和纳米载体的应用仍面临一些挑战，如快速清除和靶向效率低下。此外，由于细胞系统可以作为微米和纳米颗粒的合适替代品，它们已被用作生物载体。一般来说，稳定释放到血液、缓慢清除、高效靶向和高生物相容性等特性是用作药物载体的细胞的主要特性。此外，一些细胞如红细胞、白细胞、干细胞和血小板已被用作释放系统。因此，本文将介绍用作上述释放系统的最常见细胞。
