芥子气所致肺损伤的炎症机制
Inflammatory mechanisms of pulmonary injury induced by mustards.
作者信息
Malaviya Rama, Sunil Vasanthi R, Venosa Alessandro, Vayas Kinal N, Heck Diane E, Laskin Jeffrey D, Laskin Debra L
机构信息
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.
Department of Environmental Health Science, New York Medical College, Valhalla, NY, USA.
出版信息
Toxicol Lett. 2016 Feb 26;244:2-7. doi: 10.1016/j.toxlet.2015.10.011. Epub 2015 Oct 23.
Abstract
Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute and long term pathological consequences are observed in the lung following a single exposure to these vesicants. Evidence from our laboratories and others suggest that macrophages and the inflammatory mediators they release play an important role in mustard-induced lung injury. In this paper, the pathogenic effects of SM and NM on the lung are reviewed, along with the potential role of inflammatory macrophages and mediators they release in mustard-induced pulmonary toxicity.
摘要
人类和动物接触包括硫芥（SM）和氮芥（NM）在内的糜烂性毒剂会对呼吸道造成严重且使人衰弱的损害。单次接触这些糜烂性毒剂后，肺部会出现急性和长期的病理后果。我们实验室及其他机构的证据表明，巨噬细胞及其释放的炎症介质在芥子气诱导的肺损伤中起重要作用。本文综述了硫芥和氮芥对肺部的致病作用，以及炎症巨噬细胞及其释放的介质在芥子气诱导的肺毒性中的潜在作用。
相似文献
1
Inflammatory mechanisms of pulmonary injury induced by mustards.
Toxicol Lett. 2016 Feb 26;244:2-7. doi: 10.1016/j.toxlet.2015.10.011. Epub 2015 Oct 23.
2
Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants.
Ann N Y Acad Sci. 2016 Jun;1374(1):168-75. doi: 10.1111/nyas.13123. Epub 2016 Jun 28.
3
Protective role of spleen-derived macrophages in lung inflammation, injury, and fibrosis induced by nitrogen mustard.
Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1487-98. doi: 10.1152/ajplung.00276.2015. Epub 2015 Oct 16.
4
From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity.
Toxicol Sci. 2016 Dec;154(2):341-353. doi: 10.1093/toxsci/kfw170. Epub 2016 Sep 7.
5
Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard.
Toxicol Appl Pharmacol. 2024 Apr;485:116908. doi: 10.1016/j.taap.2024.116908. Epub 2024 Mar 19.
6
Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis.
Am J Respir Cell Mol Biol. 2016 Mar;54(3):436-46. doi: 10.1165/rcmb.2015-0120OC.
7
Conceptual approaches for treatment of phosgene inhalation-induced lung injury.
Toxicol Lett. 2016 Feb 26;244:8-20. doi: 10.1016/j.toxlet.2015.10.010. Epub 2015 Nov 10.
8
Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard.
Ann N Y Acad Sci. 2020 Nov;1480(1):146-154. doi: 10.1111/nyas.14444. Epub 2020 Aug 6.
9
Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation.
Exp Mol Pathol. 2014 Aug;97(1):89-98. doi: 10.1016/j.yexmp.2014.05.009. Epub 2014 Jun 2.
10
Long-term Respiratory Effects of Mustard Vesicants.
Toxicol Lett. 2020 Feb 1;319:168-174. doi: 10.1016/j.toxlet.2019.10.026. Epub 2019 Nov 4.
引用本文的文献
1
In Vivo Evidence of Melatonin's Protective Role in Alkylating-Agent-Induced Pulmonary Toxicity: A Systematic Review.
Antioxidants (Basel). 2025 Jun 11;14(6):712. doi: 10.3390/antiox14060712.
2
Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard.
Toxicol Appl Pharmacol. 2024 Apr;485:116908. doi: 10.1016/j.taap.2024.116908. Epub 2024 Mar 19.
3
Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation.
Disaster Med Public Health Prep. 2023 Oct 18;17:e553. doi: 10.1017/dmp.2023.178.
4
MG53 attenuates nitrogen mustard-induced acute lung injury.
J Cell Mol Med. 2022 Apr;26(7):1886-1895. doi: 10.1111/jcmm.16917. Epub 2022 Feb 24.
5
Progressive Lung Injury, Inflammation, and Fibrosis in Rats Following Inhalation of Sulfur Mustard.
Toxicol Sci. 2020 Dec 1;178(2):358-374. doi: 10.1093/toxsci/kfaa150.
6
Long-term Respiratory Effects of Mustard Vesicants.
Toxicol Lett. 2020 Feb 1;319:168-174. doi: 10.1016/j.toxlet.2019.10.026. Epub 2019 Nov 4.
7
Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard.
Toxicol Appl Pharmacol. 2020 Jan 15;387:114798. doi: 10.1016/j.taap.2019.114798. Epub 2019 Oct 31.
8
The therapeutic effects of bone marrow-derived mesenchymal stromal cells in the acute lung injury induced by sulfur mustard.
Stem Cell Res Ther. 2019 Mar 12;10(1):90. doi: 10.1186/s13287-019-1189-x.
9
Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by Nitrogen Mustard.
Toxicol Sci. 2018 Nov 1;166(1):108-122. doi: 10.1093/toxsci/kfy188.
10
Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor.
Toxicol Sci. 2017 May 1;157(1):222-234. doi: 10.1093/toxsci/kfx032.
本文引用的文献
1
Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis.
Am J Respir Cell Mol Biol. 2016 Mar;54(3):436-46. doi: 10.1165/rcmb.2015-0120OC.
2
Attenuation of Nitrogen Mustard-Induced Pulmonary Injury and Fibrosis by Anti-Tumor Necrosis Factor-α Antibody.
Toxicol Sci. 2015 Nov;148(1):71-88. doi: 10.1093/toxsci/kfv161. Epub 2015 Aug 4.
3
Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation.
Exp Mol Pathol. 2014 Aug;97(1):89-98. doi: 10.1016/j.yexmp.2014.05.009. Epub 2014 Jun 2.
4
Long-term effects of mustard gas on respiratory system of Iranian veterans after Iraq-Iran war: a review.
Chin J Traumatol. 2013;16(3):163-8.
5
Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor.
Toxicol Appl Pharmacol. 2012 Dec 15;265(3):279-91. doi: 10.1016/j.taap.2012.08.027. Epub 2012 Sep 6.
6
Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning.
Toxicol Appl Pharmacol. 2012 May 15;261(1):22-30. doi: 10.1016/j.taap.2012.03.004. Epub 2012 Mar 14.
7
Inhalation of alkylating mustard causes long-term T cell-dependent inflammation in airways and growth of connective tissue.
Toxicology. 2011 Feb 27;280(3):88-97. doi: 10.1016/j.tox.2010.11.012. Epub 2010 Dec 1.
8
Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.
Toxicol Appl Pharmacol. 2011 Feb 1;250(3):245-55. doi: 10.1016/j.taap.2010.10.027. Epub 2010 Nov 9.
9
Macrophages and tissue injury: agents of defense or destruction?
Annu Rev Pharmacol Toxicol. 2011;51:267-88. doi: 10.1146/annurev.pharmtox.010909.105812.
10
Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard.
Toxicol Appl Pharmacol. 2011 Jan 1;250(1):10-8. doi: 10.1016/j.taap.2010.09.016. Epub 2010 Sep 29.
Zotero 插件