Malaviya Rama, Sunil Vasanthi R, Venosa Alessandro, Vayas Kinal N, Heck Diane E, Laskin Jeffrey D, Laskin Debra L
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.
Department of Environmental Health Science, New York Medical College, Valhalla, NY, USA.
Toxicol Lett. 2016 Feb 26;244:2-7. doi: 10.1016/j.toxlet.2015.10.011. Epub 2015 Oct 23.
Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute and long term pathological consequences are observed in the lung following a single exposure to these vesicants. Evidence from our laboratories and others suggest that macrophages and the inflammatory mediators they release play an important role in mustard-induced lung injury. In this paper, the pathogenic effects of SM and NM on the lung are reviewed, along with the potential role of inflammatory macrophages and mediators they release in mustard-induced pulmonary toxicity.
人类和动物接触包括硫芥（SM）和氮芥（NM）在内的糜烂性毒剂会对呼吸道造成严重且使人衰弱的损害。单次接触这些糜烂性毒剂后，肺部会出现急性和长期的病理后果。我们实验室及其他机构的证据表明，巨噬细胞及其释放的炎症介质在芥子气诱导的肺损伤中起重要作用。本文综述了硫芥和氮芥对肺部的致病作用，以及炎症巨噬细胞及其释放的介质在芥子气诱导的肺毒性中的潜在作用。
