术前中性粒细胞与淋巴细胞比值是喉鳞状细胞癌患者的独立预后标志物。
Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma.
作者信息
Tu Xiu-Ping, Qiu Qian-Hui, Chen Liang-Si, Luo Xiao-Ning, Lu Zhong-Ming, Zhang Si-Yi, Chen Shao-Hua
机构信息
Department of Otorhinolaryngology, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, P. R. China.
出版信息
BMC Cancer. 2015 Oct 20;15:743. doi: 10.1186/s12885-015-1727-6.
BACKGROUND
Neutrophil-lymphocyte ratio (NLR) has been shown to be associated with prognosis in various solid tumors. This study aimed to evaluate the prognostic role of NLR in patients with laryngeal squamous cell carcinoma (LSCC).
METHODS
A total of 141 LSCC patients were retrospectively reviewed. Patients' demographics were analyzed along with clinical and pathologic data. The optimal cutoff value of NLR was determined using receiver operating characteristic (ROC) curve analysis. The impact of the NLR and other potential prognostic factors on disease-free survival (DFS) and overall survival (OS) was assessed using the Kaplan-Meier method and multivariate Cox regression analysis.
RESULTS
The optimal cutoff value of the NLR was 2.17. In the NLR ≤ 2.17 group, the 1-, 3-, and 5-year DFS rates were 88.2, 73.9 and 69.1 %, respectively, while in the NLR > 2.17 group, the DFS rates were 83.0, 54.6 and 49.2 %, respectively. Correspondingly, the 1-, 3-, and 5-year OS rates were 98.9, 85.1 and 77.4 % in the NLR ≤ 2.17 group and 97.9, 63.8 and 53.3 % in the NLR > 2.17 group, respectively. The multivariate Cox proportional hazard model analysis showed that NLR > 2.17 was a prognostic factor for both DFS [hazard ratio (HR) = 1.869; 95 % confidence interval (CI) 1.078-3.243; P = 0.026] and OS (HR =2.177; 95 % CI 1.208-3.924; P = 0.010).
CONCLUSION
Our results showed that elevated preoperative NLR was an independent predictor of poor prognosis for patients with LSCC after surgical resection.
背景
中性粒细胞与淋巴细胞比值（NLR）已被证明与多种实体瘤的预后相关。本研究旨在评估NLR在喉鳞状细胞癌（LSCC）患者中的预后作用。
方法
回顾性分析141例LSCC患者。分析患者的人口统计学资料以及临床和病理数据。采用受试者工作特征（ROC）曲线分析确定NLR的最佳临界值。使用Kaplan-Meier法和多因素Cox回归分析评估NLR和其他潜在预后因素对无病生存期（DFS）和总生存期（OS）的影响。
结果
NLR的最佳临界值为2.17。在NLR≤2.17组中，1年、3年和5年DFS率分别为88.2%、73.9%和69.1%，而在NLR＞2.17组中，DFS率分别为83.0%、54.6%和49.2%。相应地，NLR≤2.17组的1年、3年和5年OS率分别为98.9%、85.1%和77.4%，NLR＞2.17组分别为97.9%、63.8%和53.3%。多因素Cox比例风险模型分析显示，NLR＞2.17是DFS[风险比（HR）=1.869；95%置信区间（CI）1.078-3.243；P=0.026]和OS（HR=2.177；95%CI 1.208-3.924；P=0.010）的预后因素。
结论
我们的结果表明，术前NLR升高是LSCC患者手术切除后预后不良的独立预测因素。
Zotero 插件