Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
J Oral Pathol Med. 2022 Jan;51(1):39-51. doi: 10.1111/jop.13264. Epub 2021 Dec 9.
Inflammation seems to play a critical role in the development and progression of different cancers. Neutrophil-to-lymphocyte ratio (NLR) is an easily measurable marker of systemic inflammation. The purpose of this systematic review and meta-analysis was to evaluate the prognostic role of the pre-treatment NLR, in terms of overall survival (OS) and disease-free survival (DFS), in patients with primary head and neck squamous cell carcinoma (HNSCC) treated by surgery alone or followed by chemo/radiotherapy. This systematic review was performed according to the guidelines reported in the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Meta-analysis of OS and DFS was performed using the inverse of variance test. Fixed-effect models were used on the basis of the presence of heterogeneity. Risk of bias assessment and trial sequential analysis (TSA) were also performed; the quality of the evidence was evaluated via the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. The analysis revealed that a higher value of pre-treatment NLR correlates with a statistically significant decrease of OS (HR, 1.56; 95% CI: [1.35, 1.80]; p < 0.00001) and a lower DFS (HR, 1.64; 95% CI: [1.30, 2.07]; p < 0.0001) in HNSCC patients.
炎症似乎在不同癌症的发展和进展中起着关键作用。中性粒细胞与淋巴细胞比值（NLR）是一种易于测量的全身炎症标志物。本系统评价和荟萃分析的目的是评估术前 NLR 在接受单纯手术或放化疗治疗的原发性头颈部鳞状细胞癌（HNSCC）患者的总生存率（OS）和无病生存率（DFS）方面的预后作用。本系统评价按照 Cochrane 手册和系统评价和荟萃分析的 Preferred Reporting Items（PRISMA）声明中报告的指南进行。使用方差倒数检验进行 OS 和 DFS 的荟萃分析。基于异质性的存在，使用固定效应模型。还进行了偏倚风险评估和试验序贯分析（TSA）；通过 Grading of Recommendations, Assessment, Development and Evaluation（GRADE）方法评估证据质量。分析表明，术前 NLR 值较高与 OS（HR，1.56；95%CI：[1.35, 1.80]；p<0.00001）和 DFS（HR，1.64；95%CI：[1.30, 2.07]；p<0.0001）显著降低相关。
