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从脐带血、足月胎盘和成人骨髓中分离出的多能人类基质细胞在基因表达模式上表现出明显差异。

Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern.

作者信息

Matigian Nicholas, Brooke Gary, Zaibak Faten, Rossetti Tony, Kollar Katarina, Pelekanos Rebecca, Heazlewood Celena, Mackay-Sim Alan, Wells Christine A, Atkinson Kerry

机构信息

Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072, Australia ; Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia.

Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.

出版信息

Genom Data. 2014 Nov 28;3:70-4. doi: 10.1016/j.gdata.2014.11.011. eCollection 2015 Mar.

DOI:10.1016/j.gdata.2014.11.011
PMID:26484151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4535874/
Abstract

Multipotent mesenchymal stromal cells derived from human placenta (pMSCs), and unrestricted somatic stem cells (USSCs) derived from cord blood share many properties with human bone marrow-derived mesenchymal stromal cells (bmMSCs) and are currently in clinical trials for a wide range of clinical settings. Here we present gene expression profiles of human cord blood-derived unrestricted somatic stem cells (USSCs), human placental-derived mesenchymal stem cells (hpMSCs), and human bone marrow-derived mesenchymal stromal cells (bmMSCs), all derived from four different donors. The microarray data are available on the ArrayExpress database (www.ebi.ac.uk/arrayexpress) under accession number E-TABM-880. Additionally, the data has been integrated into a public portal, www.stemformatics.org. Our data provide a resource for understanding the differences in MSCs derived from different tissues.

摘要

源自人胎盘的多能间充质基质细胞(pMSCs)以及源自脐带血的无限制体细胞干细胞(USSCs),与源自人骨髓的间充质基质细胞(bmMSCs)具有许多共同特性,目前正处于针对多种临床情况的临床试验中。在此,我们展示了源自四名不同供体的人脐带血无限制体细胞干细胞(USSCs)、人胎盘间充质干细胞(hpMSCs)以及人骨髓间充质基质细胞(bmMSCs)的基因表达谱。该微阵列数据可在ArrayExpress数据库(www.ebi.ac.uk/arrayexpress)中获取,登录号为E-TABM-880。此外,这些数据已整合到一个公共门户网站www.stemformatics.org中。我们的数据为理解源自不同组织的间充质干细胞之间的差异提供了资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbcc/4535874/0e56953ef95a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbcc/4535874/c99d7692e241/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbcc/4535874/0e56953ef95a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbcc/4535874/c99d7692e241/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbcc/4535874/0e56953ef95a/gr2.jpg

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本文引用的文献

1
Stemformatics: visualisation and sharing of stem cell gene expression.干细胞信息学:干细胞基因表达的可视化与共享
Stem Cell Res. 2013 May;10(3):387-95. doi: 10.1016/j.scr.2012.12.003. Epub 2012 Dec 20.
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Unrestricted somatic stem cells from human umbilical cord blood grow in serum-free medium as spheres.人脐血无限制体干细胞在无血清培养基中可长成球体。
BMC Biotechnol. 2009 Dec 15;9:101. doi: 10.1186/1472-6750-9-101.
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Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials.用于临床试验的人胎盘源间充质干细胞的制造。
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Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells.人胎盘源与骨髓源多能间充质干细胞的比较
Stem Cells Dev. 2008 Dec;17(6):1095-107. doi: 10.1089/scd.2007.0154.
5
A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential.一种来自胎盘脐带血的具有内在多能分化潜能的新型人类体细胞干细胞。
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