从脐带血、足月胎盘和成人骨髓中分离出的多能人类基质细胞在基因表达模式上表现出明显差异。
Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern.
作者信息
Matigian Nicholas, Brooke Gary, Zaibak Faten, Rossetti Tony, Kollar Katarina, Pelekanos Rebecca, Heazlewood Celena, Mackay-Sim Alan, Wells Christine A, Atkinson Kerry
机构信息
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072, Australia ; Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia.
Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
出版信息
Genom Data. 2014 Nov 28;3:70-4. doi: 10.1016/j.gdata.2014.11.011. eCollection 2015 Mar.
Multipotent mesenchymal stromal cells derived from human placenta (pMSCs), and unrestricted somatic stem cells (USSCs) derived from cord blood share many properties with human bone marrow-derived mesenchymal stromal cells (bmMSCs) and are currently in clinical trials for a wide range of clinical settings. Here we present gene expression profiles of human cord blood-derived unrestricted somatic stem cells (USSCs), human placental-derived mesenchymal stem cells (hpMSCs), and human bone marrow-derived mesenchymal stromal cells (bmMSCs), all derived from four different donors. The microarray data are available on the ArrayExpress database (www.ebi.ac.uk/arrayexpress) under accession number E-TABM-880. Additionally, the data has been integrated into a public portal, www.stemformatics.org. Our data provide a resource for understanding the differences in MSCs derived from different tissues.
源自人胎盘的多能间充质基质细胞（pMSCs）以及源自脐带血的无限制体细胞干细胞（USSCs），与源自人骨髓的间充质基质细胞（bmMSCs）具有许多共同特性，目前正处于针对多种临床情况的临床试验中。在此，我们展示了源自四名不同供体的人脐带血无限制体细胞干细胞（USSCs）、人胎盘间充质干细胞（hpMSCs）以及人骨髓间充质基质细胞（bmMSCs）的基因表达谱。该微阵列数据可在ArrayExpress数据库（www.ebi.ac.uk/arrayexpress）中获取，登录号为E-TABM-880。此外，这些数据已整合到一个公共门户网站www.stemformatics.org中。我们的数据为理解源自不同组织的间充质干细胞之间的差异提供了资源。
Zotero 插件