人胰腺导管腺癌中环状RNA的基因芯片表达谱
Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma.
作者信息
Qu Shibin, Song Wenjie, Yang Xisheng, Wang Jianlin, Zhang Ruohan, Zhang Zhuochao, Zhang Hongtao, Li Haimin
机构信息
Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
出版信息
Genom Data. 2015 Jul 21;5:385-7. doi: 10.1016/j.gdata.2015.07.017. eCollection 2015 Sep.
Pancreatic ductal adenocarcinoma (PDAC) remains a common and deadly cancer. Despite numerous efforts, no reliable biomarker is available for daily clinical practice. Circular RNAs (circRNAs) are an abundant, stable and conserved class of RNA molecules that exhibit tissue/developmental-stage-specific expression (Salzman et al., 2012; Jeck et al., 2013; Memczak et al., 2013). CircRNAs play a crucial role in disease, especially in cancer, and provide new potential diagnostic and therapeutic targets for disease (Hansen et al., 2013; Qu et al., 2015).This research was designed to explore the expression profile of circRNAs in PDAC to serve as new diagnosis and treatment strategies for PDAC. Microarray and sample annotation data were deposited in Gene Expression Omnibus (GEO) under accession number GSE69362.
胰腺导管腺癌（PDAC）仍然是一种常见且致命的癌症。尽管付出了诸多努力，但日常临床实践中仍没有可靠的生物标志物可用。环状RNA（circRNAs）是一类丰富、稳定且保守的RNA分子，表现出组织/发育阶段特异性表达（萨尔兹曼等人，2012年；杰克等人，2013年；梅姆扎克等人，2013年）。CircRNAs在疾病尤其是癌症中发挥着关键作用，并为疾病提供了新的潜在诊断和治疗靶点（汉森等人，2013年；曲等人，2015年）。本研究旨在探索circRNAs在PDAC中的表达谱，以为PDAC提供新的诊断和治疗策略。微阵列和样本注释数据已存入基因表达综合数据库（GEO），登录号为GSE69362。
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