Yoon Hye-Jin, Lee Yong-Ho, Kim Kwang Joon, Kim So Ra, Kang Eun Seok, Cha Bong-Soo, Lee Hyun Chul, Lee Byung-Wan
Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea ; Severance Hospital, Seoul, Republic of Korea.
Severance Executive Healthcare Clinic, Yonsei University Health System, Seoul, Republic of Korea.
Biomed Res Int. 2015;2015:576306. doi: 10.1155/2015/576306. Epub 2015 Sep 21.
We recently reported that glycated albumin (GA) is increased in subjects with longer duration of diabetes and with decreased insulin secretory function. Based on this, we investigated whether GA increases with time relative to glycated hemoglobin (HbA1c) and the association between GA and beta-cell function. We analyzed 340 type 2 diabetes patients whose serum GA and HbA1c levels had been repeatedly measured over 4 years. We assessed the pattern of changes with time in glycemic indices (GA, HbA1c, and GA/HbA1c ratio) and their relationship with beta-cell function. In all patients, glycemic indices decreased and maintained low levels around 15 and 27 months. However, from 39 months to 51 months, GA significantly increased but HbA1c tended to increase without statistical significance. We defined ΔGA/HbA1c as the difference between the nadir point (at 15 to 27 months) and the end point (at 39 to 51 months) and found that ΔGA/HbA1c was positively correlated with diabetes duration and negatively related to beta-cell function. In multivariable linear regression analyses, ΔGA/HbA1c was independently associated with diabetes duration. In conclusion, this study demonstrated that serum GA levels increase relative to HbA1c levels with time.
我们最近报告称，糖尿病病程较长且胰岛素分泌功能下降的患者糖化白蛋白（GA）水平升高。基于此，我们研究了相对于糖化血红蛋白（HbA1c），GA是否随时间增加，以及GA与β细胞功能之间的关联。我们分析了340例2型糖尿病患者，这些患者的血清GA和HbA1c水平在4年期间被反复测量。我们评估了血糖指标（GA、HbA1c和GA/HbA1c比值）随时间的变化模式及其与β细胞功能的关系。在所有患者中，血糖指标在15个月和27个月左右下降并维持在低水平。然而，从39个月到51个月，GA显著升高，但HbA1c虽有升高趋势但无统计学意义。我们将ΔGA/HbA1c定义为最低点（15至27个月时）与终点（39至51个月时）之间的差值，发现ΔGA/HbA1c与糖尿病病程呈正相关，与β细胞功能呈负相关。在多变量线性回归分析中，ΔGA/HbA1c与糖尿病病程独立相关。总之，本研究表明，血清GA水平随时间相对于HbA1c水平升高。
