Schoen R T, Vender R J
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
Am J Med. 1989 Apr;86(4):449-58. doi: 10.1016/0002-9343(89)90344-6.
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the gastric mucosa are well documented. The complex mechanisms of gastric damage, however, are not fully understood. This review examines current knowledge about the normal function of the gastric mucosal barrier; the role of prostaglandins in cytoprotection and repair; the mechanisms by which aspirin and other weak organic acids are absorbed by the stomach; and the subsequent cascade of events--including ion trapping and back diffusion of hydrogen ions--that leads to gastric erosion and bleeding. A hypothesis describing NSAIDs' dual insult on the stomach is advanced.
非甾体抗炎药（NSAIDs）对胃黏膜的影响已有充分记载。然而，胃损伤的复杂机制尚未完全明了。本综述探讨了有关胃黏膜屏障正常功能的现有知识；前列腺素在细胞保护和修复中的作用；阿司匹林及其他弱有机酸被胃吸收的机制；以及随后导致胃糜烂和出血的一系列事件，包括离子捕获和氢离子反向扩散。本文提出了一种描述NSAIDs对胃双重损害的假说。
