来自海洋来源的多疣链霉菌的1,3-恶嗪-6-酮衍生物和波希米亚胺型吡咯里西啶生物碱。
1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus.
作者信息
Fu Peng, La Scott, MacMillan John B
机构信息
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas , Dallas, Texas 75390, United States.
出版信息
J Nat Prod. 2016 Mar 25;79(3):455-62. doi: 10.1021/acs.jnatprod.5b00604. Epub 2015 Oct 21.
Abstract
Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3-8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess a γ-lactam moiety and a 1,3-oxazin-6-one system.
摘要
从海洋来源的多疣链霉菌菌株SNB - 048中分离出两种新的1,3 - 恶嗪 - 6 - 酮衍生物（1和2）以及六种新的波希米亚明型吡咯里西啶生物碱（3 - 8）。基于光谱分析、ECD光谱、量子化学计算和化学方法，全面阐明了它们包括绝对构型在内的结构。化合物1和2具有一个γ - 内酰胺部分和一个1,3 - 恶嗪 - 6 - 酮体系。
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