Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
J Antibiot (Tokyo). 2018 Nov;71(11):965-967. doi: 10.1038/s41429-018-0084-5. Epub 2018 Aug 29.
A quinoxalinone-bohemamine hybrid compound quinohemanine (1), together with 1-methyl-2(H)-quinoxalin-2-one (2), was isolated from Streptomyces sp. CPCC 200497, a producer of quinomycins and bohemamines. Compounds 1 and 2 were purified using standard chromatographic methods, and their structures were defined through interpretation of HRMS, 1D, and 2D NMR data. Both 1 and 2 displayed moderate cytotoxicity against cancer cell line HepG2.
从产生醌霉素和博海姆胺的链霉菌 CPCC 200497 中分离到一种喹喔啉酮-博海胺混合化合物喹诺海明（1）和 1-甲基-2（H）-喹喔啉-2-酮（2）。采用标准色谱方法对化合物 1 和 2 进行纯化，并通过高分辨质谱、一维和二维 NMR 数据分析确定其结构。化合物 1 和 2 对肝癌细胞系 HepG2 均表现出中等的细胞毒性。
