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通过铑催化三唑与醛的环化反应合成2,5-二芳基恶唑

Synthesis of 2,5-diaryloxazoles through rhodium-catalyzed annulation of triazoles and aldehydes.

作者信息

Li Jian, Zhu Shang-Rong, Xu Yue, Lu Xue-Chen, Wang Zheng-Bing, Liu Li, Xu De-Feng

机构信息

Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Pharmaceutical Engineering & Life Sciences, Changzhou University Changzhou 213164 China

出版信息

RSC Adv. 2020 Jun 30;10(42):24795-24799. doi: 10.1039/d0ra03966g. eCollection 2020 Jun 29.

DOI:10.1039/d0ra03966g
PMID:35517461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9055139/
Abstract

An efficient synthesis of a variety of 2,5-diaryloxazole derivatives a rhodium-catalyzed annulation of triazoles and aldehydes is achieved. Various oxazole derivatives could be obtained in good to excellent yields. A concise synthesis of antimycobaterial natural products balsoxin and texamine has been achieved using this method.

摘要

通过铑催化的三唑与醛的环化反应，实现了多种2,5 - 二芳基恶唑衍生物的高效合成。各种恶唑衍生物能够以良好至优异的产率获得。利用该方法已实现了抗分枝杆菌天然产物巴洛毒素和特沙明的简洁合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/747f601a738b/d0ra03966g-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/144e39cb0e78/d0ra03966g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/e1e0bd2780b9/d0ra03966g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/7508b9c8d07b/d0ra03966g-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/747f601a738b/d0ra03966g-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/144e39cb0e78/d0ra03966g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/e1e0bd2780b9/d0ra03966g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/7508b9c8d07b/d0ra03966g-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8534/9055139/747f601a738b/d0ra03966g-s4.jpg

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