Kourlaba Georgia, Relakis John, Kontodimas Stathis, Holm Majbrit V, Maniadakis Nikos
The Stavros Niarchos Foundation-Collaborative Center for Clinical Epidemiology and Outcomes Research, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
Department of Health Services Organization and Management, National School of Public Health, Athens, Greece.
Int J Gynaecol Obstet. 2016 Jan;132(1):4-10. doi: 10.1016/j.ijgo.2015.06.054. Epub 2015 Oct 9.
Pregnancy-related venous thromboembolism (VTE) is one of the leading causes of maternal morbidity and mortality.
To review the epidemiology, and humanistic and economic burden of pregnancy-related VTE.
Medline, the Cochrane Central Register of Controlled Trials, Econlit, Science Direct, JSTOR, Oxford Journals, and Cambridge Journals were searched for reports published between January 2000 and December 2012. Keywords related to VTE, pregnancy, and epidemiology and the humanistic and economic burdens were combined.
Eligible studies evaluated the incidence, mortality, recurrence, complications, quality-of-life, and economic burden of VTE among pregnant women, and had been published in English.
Background information of the study, participants' characteristics, and study outcomes were collected. Meta-analyses of data were performed.
Twenty studies were included, none of which investigated the economic burden. The pooled overall incidence of pregnancy-related VTE was 1.2 per 1000 deliveries. The pooled VTE case fatality rate was 0.68% and the recurrence rate was 4.27%. The pooled risk of major bleeding was 1.05%. Post-thrombotic syndrome seemed to have a negative effect on quality of life.
Although the incidence of VTE was found to be relatively low during pregnancy and the postpartum period, the clinical burden is high. Further research is required to assess the economic burden of pregnancy-relate VTE.
妊娠相关静脉血栓栓塞症（VTE）是孕产妇发病和死亡的主要原因之一。
综述妊娠相关VTE的流行病学、人文及经济负担。
检索了Medline、Cochrane对照试验中心注册库、Econlit、Science Direct、JSTOR、牛津期刊和剑桥期刊，以查找2000年1月至2012年12月期间发表的报告。将与VTE、妊娠、流行病学以及人文和经济负担相关的关键词进行了组合。
符合条件的研究评估了孕妇VTE的发病率、死亡率、复发率、并发症、生活质量和经济负担，且已以英文发表。
收集了研究的背景信息、参与者特征和研究结果。对数据进行了荟萃分析。
纳入了20项研究，其中没有一项研究调查经济负担。妊娠相关VTE的合并总体发病率为每1000例分娩1.2例。VTE合并病死率为0.68%，复发率为4.27%。大出血的合并风险为1.05%。血栓形成后综合征似乎对生活质量有负面影响。
尽管在孕期和产后VTE的发病率相对较低，但临床负担较高。需要进一步研究以评估妊娠相关VTE的经济负担。
