Hoyer Dirk, Schneider Uwe, Kowalski Eva-Maria, Schmidt Alexander, Witte Otto W, Schleußner Ekkehard, Hatzmann Wolfgang, Grönemeyer Dietrich Hw, van Leeuwen Peter
Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, 07743, Germany.
Physiol Meas. 2015 Nov;36(11):2369-78. doi: 10.1088/0967-3334/36/11/2369. Epub 2015 Oct 22.
With the objective of evaluating the functional maturation age and developmental disturbances we have previously introduced the fetal autonomic brain age score (fABAS) using 30 min fetal magnetocardiographic recordings (fMCG, Jena). The score is based on heart rate pattern indices that are related to universal principles of developmental biology. The present work aims at the validation of the fABAS methodology on 5 min recordings from an independent database (fMCG, Bochum).We found high agreement of fABAS obtained from Jena normal fetuses (5 min subsets, n = 364) and Bochum recordings (n = 322, normal fetuses). fABAS of 48 recordings from fetuses with intra-uterine growth restriction (IUGR, Bochum) was reduced in most of the cases, a result consistent with IUGR fetuses from Jena previously reported. fABAS calculated from 5 min snapshots only partly covers the accuracy when compared to fABAS from 30 min recordings. More precise diagnosis requires longer recordings.fABAS obtained from fMCG recordings is a strong candidate for standardized assessment of functional maturation age and developmental disturbances. Even 5 min recordings seem to be valuable for screening for maturation problems.
为了评估功能成熟年龄和发育障碍，我们之前采用30分钟的胎儿磁心动图记录（fMCG，耶拿）引入了胎儿自主脑年龄评分（fABAS）。该评分基于与发育生物学普遍原理相关的心率模式指标。目前的工作旨在根据来自独立数据库（fMCG，波鸿）的5分钟记录对fABAS方法进行验证。我们发现，从耶拿正常胎儿（5分钟子集，n = 364）和波鸿记录（n = 322，正常胎儿）获得的fABAS高度一致。来自波鸿宫内生长受限（IUGR）胎儿的48份记录的fABAS在大多数情况下降低，这一结果与之前报道的耶拿IUGR胎儿一致。与30分钟记录的fABAS相比，从5分钟快照计算出的fABAS仅部分涵盖准确性。更精确的诊断需要更长的记录。从fMCG记录获得的fABAS是功能成熟年龄和发育障碍标准化评估的有力候选指标。即使是5分钟的记录似乎对筛查成熟问题也很有价值。
