Emamifar A, Gildberg-Mortensen Rannveig, Andreas Just S, Lomborg N, Asmussen Andreasen R, Jensen Hansen I M
Department of Rheumatology, University Hospital of Odense, Svendborg Hospital, Valdemarsgade 51, 5700 Svendborg, Denmark.
Int J Rheumatol. 2015;2015:783709. doi: 10.1155/2015/783709. Epub 2015 Sep 29.
Objective. To estimate level of adherence to oral calcium and vitamin D supplementation as well as bisphosphonate amongst patients with PMR and GCA treated with glucocorticoids. Method. A total of 138 patients with the diagnosis of PMR and/or GCA registered in our department in December 2013. In this cross-sectional study we interviewed all the patients to measure level of adherence to calcium and vitamin D, as well as bisphosphonates. Results. Out of the 118 included patients, 88.9% of them were adherent to their prescription. Only 2 patients (1.7%) did not take calcium and vitamin D at all and 10 patients (8.5%) took their medication infrequently, 9 and 1 out of 10 patients took the medication 50-100% of the time and less than 50% of the prescribed dose, respectively. Sixty-one patients received additional treatment with bisphosphonate and 96.6% were adherent to this therapy. The remaining 3.4% of the patients did not take the medication at all. Forgetfulness, adverse side effects, and lack of understanding of treatment benefits were the most significant causes for nonadherence to calcium and vitamin D. Conclusions. Contrary to what we expected this study found that adherence to osteoporosis preventive medication in patients with PMR and GCA was high.
目的。评估糖皮质激素治疗的巨细胞动脉炎(GCA)和风湿性多肌痛(PMR)患者口服钙和维生素D补充剂以及双膦酸盐的依从性水平。方法。2013年12月在我科登记诊断为PMR和/或GCA的患者共138例。在这项横断面研究中,我们对所有患者进行访谈以测量其对钙、维生素D以及双膦酸盐的依从性水平。结果。在纳入研究的118例患者中,88.9%的患者依从医嘱。仅有2例患者(1.7%)完全未服用钙和维生素D,10例患者(8.5%)偶尔服药,10例患者中分别有9例和1例服药时间为规定时间的50%-100%以及低于规定剂量的50%。61例患者接受了双膦酸盐的额外治疗,96.6%的患者依从该治疗。其余3.4%的患者完全未服药。遗忘、不良副作用以及对治疗益处缺乏了解是不依从钙和维生素D治疗的最主要原因。结论。与我们的预期相反,本研究发现PMR和GCA患者对骨质疏松预防药物的依从性较高。