营养不良与肠道菌群失调：心力衰竭新出现的合并症的特异性治疗方法
Malnutrition and Gut Flora Dysbiosis: Specific Therapies for Emerging Comorbidities in Heart Failure.
作者信息
Pasini Evasio, Aquilani Roberto, Corsetti Giovanni, Dioguardi Francesco S
机构信息
"S. Maugeri Foundation" IRCCS, Medical Centre, Lumezzane, 25065 Brescia, Italy.
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
出版信息
Biomed Res Int. 2015;2015:382585. doi: 10.1155/2015/382585. Epub 2015 Sep 30.
Abstract
Chronic heart failure is a complicated multifactorial disease with wide-spread social-economic consequences. In spite of the recent development of new drugs and therapeutic strategies, CHF-related mortality and morbidity remain high. Recent evidence suggests that changes in organs such as skeletal muscle and gut flora may play an important and independent role in CHF prognosis. This paper illustrates these phenomena, proposing how to identify them and presenting current therapies which treat organs all too often underestimated but which have a fundamental role in worsening CHF.
摘要
慢性心力衰竭是一种复杂的多因素疾病，具有广泛的社会经济后果。尽管近年来新药和治疗策略不断发展，但与慢性心力衰竭相关的死亡率和发病率仍然很高。最近的证据表明，骨骼肌和肠道菌群等器官的变化可能在慢性心力衰竭的预后中发挥重要且独立的作用。本文阐述了这些现象，提出了如何识别它们，并介绍了目前针对那些常常被低估但在慢性心力衰竭恶化中起关键作用的器官的治疗方法。
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